That code indicates a problem with just one ignition coil (coil E) in a COP system. Missing spark on just one cylinder should not prevent the engine from firing and running.
You say "won't start"; does that mean "crank but no fire", or "no crank"?
If it does crank, have you checked for spark at all cylinders? Checked fuel pressure with a gauge? Will it fire and run briefly with a quick blast of starting-fluid? You should use live-data to check all the engine sensors.
What is your intent here, are you a DIYer that will be digging into this personally, or just seeking some background info before taking it to a shop for repair?